Cd14 genotype and functional dichotomy of cd14+ and cd14- cells are associated with activated immune response and development of chagas dilated cardiomyopathy
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Universidade Federal de Minas Gerais
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Artigo de periódico
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Membros da banca
Resumo
Chagas disease cardiomyopathy is the most severe outcome of the infection with the protozoan Trypano soma cruzi, responsible for over 10,000 deaths annually. There are currently over 100 million people at risk of infection with T. cruzi and, of those, at least 30% may
develop the deadly cardiomyopathy. There is no vaccine to prevent the disease and no markers to identify indi viduals at risk of developing the severe form. The great clinical variability of chronic Chagas disease is directly associated with the host’s immune response.(1,2) Research from our group has previously shown that CD14+ monocytes are critical cells in determining
the inflammatory and anti-inflammatory immunological profile observed in chronic cardiac and asymptomatic (indeterminate) Chagas patients, respectively.(1) In addition, T. cruzi strains have been associated with severe and mild infections and profoundly affect the response of CD14+ monocytes, inducing an inflammatory or regula tory profile in these cells, respectively.
Abstract
Assunto
Chagas cardiomyopathy, Lipopolysaccharide Receptors
Palavras-chave
Chagas cardiomyopathy, CD14, Polymorphism
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doi:10.1590/0074-02760200110