Cd14 genotype and functional dichotomy of cd14+ and cd14- cells are associated with activated immune response and development of chagas dilated cardiomyopathy

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dc.creatorGermano Carneirocosta
dc.creatorManoel Otávio da Costa Rocha
dc.creatorPaulo Eduardo Alencar de Souza
dc.creatorDiego Felipe sa Melo
dc.creatorPaula Rocha Moreira
dc.creatorKenneth John Gollob
dc.creatorMaria do Carmo Pereira Nunes
dc.creatorWalderez Ornelas Dutra
dc.date.accessioned2024-01-10T21:08:30Z
dc.date.accessioned2025-09-08T23:01:22Z
dc.date.available2024-01-10T21:08:30Z
dc.date.issued2020
dc.format.mimetypepdf
dc.identifier.doi10.1590/0074-02760200110
dc.identifier.issn16788060
dc.identifier.urihttps://hdl.handle.net/1843/62555
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz
dc.rightsAcesso Aberto
dc.subjectChagas cardiomyopathy
dc.subjectLipopolysaccharide Receptors
dc.subject.otherChagas cardiomyopathy
dc.subject.otherCD14
dc.subject.otherPolymorphism
dc.titleCd14 genotype and functional dichotomy of cd14+ and cd14- cells are associated with activated immune response and development of chagas dilated cardiomyopathy
dc.typeArtigo de periódico
local.citation.epage5
local.citation.issuee200110
local.citation.spage1
local.citation.volume115
local.description.resumoChagas disease cardiomyopathy is the most severe outcome of the infection with the protozoan Trypano soma cruzi, responsible for over 10,000 deaths annually. There are currently over 100 million people at risk of infection with T. cruzi and, of those, at least 30% may develop the deadly cardiomyopathy. There is no vaccine to prevent the disease and no markers to identify indi viduals at risk of developing the severe form. The great clinical variability of chronic Chagas disease is directly associated with the host’s immune response.(1,2) Research from our group has previously shown that CD14+ monocytes are critical cells in determining the inflammatory and anti-inflammatory immunological profile observed in chronic cardiac and asymptomatic (indeterminate) Chagas patients, respectively.(1) In addition, T. cruzi strains have been associated with severe and mild infections and profoundly affect the response of CD14+ monocytes, inducing an inflammatory or regula tory profile in these cells, respectively.
local.publisher.countryBrasil
local.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externadoi:10.1590/0074-02760200110

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