Use este identificador para citar ou linkar para este item:
http://hdl.handle.net/1843/44446| Tipo: | Artigo de Periódico |
| Título: | Is the “lactormone” a key-factor for exercise-related neuroplasticity? A hypothesis based on an alternative lactate neurobiological pathway |
| Autor(es): | Renato Sobral Monteiro Junior Pauline Maillot Valeska Gatica-Rojas Waldney Roberto de Matos e Ávila Alfredo Maurício Batista de Paula André Luiz Sena Guimarães Sergio Henrique Sousa Santos Camila Castelo Branco Pupe Andréa Camaz Deslandes |
| Resumo: | For many years lactate was seen as a metabolite from glucose metabolism. However, since the last century researchers have shown that this molecule has an important role on liver, muscle, and brain metabolism. Lactate traffics along whole body mediating many biological processes depending on specific situations. For example, glucose is the main substrate used during exercise but lactate released by striated skeletal muscle is used by own muscle as secondary fuel. On the other hand, neuronal firing in the brain is almost totally lactate-dependent. In addition, lactate has an important role on BDNF-mediated neuroplasticity. As this molecule has a pleiotropic role in the body, it was called as “lactormone” in 2009. Here we show basic concepts on peripheral and central metabolism and discuss neurobiological pathways of lactate, including an alternative hypothesis on lactate released during exercise. |
| Assunto: | Lactatos Ácido pirúvico Exercícios físicos Neuroplasticidade Glicose Neurociências |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1016/j.mehy.2018.12.013 |
| URI: | http://hdl.handle.net/1843/44446 |
| Data do documento: | Fev-2019 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0306987718310946?via%3Dihub |
| metadata.dc.relation.ispartof: | Medical Hypotheses |
| Aparece nas coleções: | Artigo de Periódico |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Is the lactormone a key-factor for exercise-related neuroplasticity.pdf | 724.38 kB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.