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http://hdl.handle.net/1843/44508| Type: | Artigo de Periódico |
| Title: | The usefulness of short-term high-fat/high salt diet as a model of metabolic syndrome in mice |
| Authors: | Leônidas das Graças Mendes Júnior Leandro Ceotto Freitas Lima Janaína Ribeiro Oliveira Marcos de Abreu Melo John David Feltenberger Igor Viana Brandi Bruna Mara Aparecida Carvalho André Luiz Sena Guimarães Alfredo Maurício Batista de Paula Carlos Eduardo Mendes D'Angelis Maria José Campagnole Santos Robson Augusto Souza Santos Valdir Andrade Braga Sérgio Henrique Sousa Santos |
| Abstract: | Diabetic cardiomyopathy (DC) describes diabetes-associated changes in the structure and function of myocardium that are not directly linked to other factors such as hypertension. Currently there are some models of DC; however, they take a large time period to mimic key features. In the present study, we investigated the effects of a short-term high-fat/high salt diet (HFHS) treatment on myocardial function and structure, and vascular reactivity in C57BL/6 male mice. After 14 weeks HFHS induced hypertension (MAP = 144.95 ± 16.13 vs 92.90 ± 18.95 mm Hg), low glucose tolerance (AUC = 1049.01 ± 74.79 vs 710.50 ± 52.57 a.u.), decreased insulin sensitivity (AUC = 429.83 ± 35.22 vs 313.67 ± 19.55 a.u.) and increased adiposity (epididymal fat weight 0.96 ± 0.10 vs 0.59 ± 0.06 OW/BW × 102), aspects present in metabolic syndrome. Cardiac evaluation showed diastolic dysfunction (E/A ratio = 1.20 vs 1.90 u.a.) and cardiomyocyte hypertrophy (cardiomyocyte area = 502.82 ± 31.46 vs 385.58 ± 22.11 μm2). Lastly, vascular reactivity was impaired with higher contractile response (136.10 ± 3.49 vs 120.37 ± 5.43%) and lower response to endothelium-dependent vasorelaxation (74.01 ± 4.35 vs 104.84 ± 3.57%). In addition, the diet was able to induce an inward coronary remodeling (vascular total area: SCNS 6185 ± 800.6 vs HFHS 4085 ± 213.7 μm2). Therefore, we conclude that HFHS short-term treatment was able to induce metabolic syndrome-like state, cardiomyopathy and vascular injury working as an important tool to study cardiometabolic diseases. |
| Subject: | Síndrome metabólica Obesidade Miocárdio - Doenças Diabetes |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.lfs.2018.08.034 |
| URI: | http://hdl.handle.net/1843/44508 |
| Issue Date: | 15-Sep-2018 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S002432051830479X?via%3Dihub#! |
| metadata.dc.relation.ispartof: | Life Sciences |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| The usefulness of short-term high-fathigh salt diet as a model of metabolic syndrome in mice.pdf | 1.02 MB | Adobe PDF | View/Open |
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