Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/48831| Type: | Artigo de Periódico |
| Title: | The angiotensin converting enzyme 2 (ACE2), gut microbiota, and cardiovascular health |
| Authors: | Joao Marcus Oliveira Andrade Deborah de Farias Lelis Valeria Mafra Cota Júnio Cota Silva |
| Abstract: | Background: The renin-angiotensin system (RAS) is an important enzymatic system responsible for the regulation of biological functions, such as the arterial pressure, hydroelectrolytic control, vascular vasodilatation/vasoconstriction and more recently metabolic functions. Objectives: The aim of the present review is to discuss the associations between the gut microbiome and the renin-angiotensin system and the influence of their intimate relationship on the cardiovascular health. Methods: A literature review of the main studies published regarding the relationship among the renin-angiotensin system, gut microbiota and cardiovascular health was performed. Results: The association between the ACE2 and gut microbiota has been discussed. It is shown that the ACE2/Ang 1-7 axis modulates the immune response, influencing the microbiota composition, and thus being one of the causes for some diseases physiophatologies, such as diarrhea and intestinal inflammatory disease. Conclusion: The association between RAS and gut microbiota seems to have a strong influence on the genesis of cardiovascular diseases, through direct mechanisms, such as nerve stimulation, or indirectly on metabolic parameters, such as weight, adiposity and lipid profile. |
| Subject: | Enzima conversora da angiotensina Sistema cardiovascular |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| URI: | http://hdl.handle.net/1843/48831 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | http://www.eurekaselect.com/article/85062 |
| metadata.dc.relation.ispartof: | Protein & Peptide Letters |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.