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Type:	Artigo de Periódico
Title:	Alpha-Actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game
Authors:	Daniel Barbosa Coelho Eduardo Mendonça Pimenta Izinara Cruz Rosse Christiano Veneroso Guilherme de Azambuja Pussieldi Lenice Kappes Becker Emerson Cruz de Oiveira Maria Raquel Santos Carvalho Emerson Silami Garcia
Abstract:	Coelho, DB, Pimenta, EM, Rosse, IC, Veneroso, C, Pussieldi, GDA, Becker, LK, De Oliveira, EC, Carvalho, MRS, and Silami-Garcia, E. Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game. J Strength Cond Res 33(10): 2655–2664, 2019—The purpose of this study was to evaluate indicators of muscle damage and hormonal responses after soccer matches and its relation to alpha-actinin-3 (ACTN3) gene expression (XX vs. RR/RX), considering that the R allele produces alpha-actinin-3 and provides greater muscle strength and power. Thirty players (10 XX and 20 RR/RX) younger than 16 years were evaluated in this study. Blood samples were collected immediately before, after, 2, and 4 hours after the games to assess muscle damage (creatine kinase [CK] and alpha-actin) and hormonal responses (interleukin-6 [IL-6], cortisol, and testosterone). Postgame CK was higher as compared to the pregame values in both groups and it was also higher in the RR/RX (p < 0.05) than in the XX. The concentrations of alpha-actin and IL-6 were similar for both groups and did not change over time. Testosterone was increased after the game only in the RR/RX group (p < 0.05). Cortisol concentrations in group RR/RX were higher immediately after the game than before the game, and 2 and 4 hours after the game the concentration decreased (p < 0.05). The RR and RX individuals presented higher markers of muscle microtrauma and hormonal stress, probably because they performed more speed and power actions during the game, which is a self-regulated activity. From the different responses presented by RR/RX and XX genotypes, we conclude that the genotypic profile should be taken into account when planning training workloads and recovery of athlete.
Subject:	Genética - Expressão Estresse fisiológico Avaliação de desempenho Proteína de ligação Ferimentos e lesões Marcadores biológicos / sangue
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	EEF - DEPARTAMENTO DE ESPORTES
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1519/JSC.0000000000002575
URI:	http://hdl.handle.net/1843/50361
Issue Date:	Oct-2019
metadata.dc.url.externa:	https://journals.lww.com/nsca-jscr/Fulltext/2019/10000/Alpha_Actinin_3_R577X_Polymorphism_Influences.10.aspx
metadata.dc.relation.ispartof:	Journal of Strength and Conditioning Research
Appears in Collections:	Artigo de Periódico

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