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http://hdl.handle.net/1843/52497| Type: | Artigo de Periódico |
| Title: | Liver damage produced by malnutrition is improved by dietary supplementation in mice: assessment of a supplement based on buriti (a cerrado fruit) and dairy by-products |
| Authors: | Audrey Handyara Bicalho Fabio Ribeiro dos Santos Daniele Cristina Moreira Luís Paulo Oliveira Amanda Souto Machado Lucyana Conceição Farias Alfredo Maurício Batista de Paula André Luiz Sena Guimarães Sergio Henrique Sousa Santos |
| Abstract: | Background: malnutrition induced by dietary restriction produces several metabolic changes that affect body weight, the digestive system, and annex organs, including the liver. Malnutrition generates an inflammatory state and increases oxidative stress. The liver is one of the body vital organs, becoming necessary to analyze the impact of food supplementation on the repair of possible changes that may occur in this organ due to malnutrition. Aims: to evaluate the effects of a low-cost supplementation derived from Buriti and dairy byproducts on liver recovery in malnourished mice, focusing on the expression of oxidative stressrelated genes, as well as biochemical and histological parameters. Methods: swiss mice were divided into six groups and submitted to two treatment phases: food restriction, for malnutrition onset; and renutrition, with mice being fed with different diets. Results: our results indicate that dietary supplementation was successful in recovering liver damage caused by malnutrition in animal models. The new supplement has been shown to recover liver damage with similar or superior results compared to the commercial reference supplement on the market. Conclusion: our work presents a new composition of low cost food supplement based on buriti and dairy by-products, proven to be effective in the malnutrition treatment of malnutrition. The improvements were proven through the recovery of body weight, reduction of inflammation and oxidative stress. |
| Subject: | Desnutrição Suplementos dietéticos Fígado - Doenças Estresse oxidativo Buriti |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.2174/2212798411999210101224626 |
| URI: | http://hdl.handle.net/1843/52497 |
| Issue Date: | 1-Jan-2021 |
| metadata.dc.url.externa: | https://www.eurekaselect.com/article/112970 |
| metadata.dc.relation.ispartof: | Recent Patents on Food, Nutrition & Agriculture |
| Appears in Collections: | Artigo de Periódico |
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