Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56277
Type: Artigo de Periódico
Title: Developmental exposure to the flame retardant mixture firemaster 550 compromises adult bone integrity in male but not female rats
Authors: Soraia Macari
Kylie D. Rock
Mariana S. Santos
Virgínia T. M. Lima
Raphael Escorsim Szawka
Jamal Moss
Brian Horman
Heather B. Patisaul
Abstract: Flame retardants (FRs) are used in a variety of common items from furniture to carpet to electronics to reduce flammability and combustion, but the potential toxicity of these compounds is raising health concerns globally. Organophosphate FRs (OPFRs) are becoming more prevalent as older, brominated FRs are phased out, but the toxicity of these compounds, and the FR mixtures that contain them, is poorly understood. Work in a variety of in vitro model systems has suggested that FRs may induce metabolic reprogramming such that bone density is compromised at the expense of increasing adiposity. To address this hypothesis, the present studies maternally exposed Wistar rat dams orally across gestation and lactation to 1000 µg daily of the FR mixture Firemaster 550 (FM 550) which contains a mixture of brominated FRs and OPFRs. At six months of age, the offspring of both sexeswereexaminedforevidenceofcompromisedbonecomposition. Bonedensity,composition,and marrow were all significantly affected, but only in males. The fact that the phenotype was observed months after exposure suggests that FM 550 altered some fundamental aspect of mesenchymal stem cell reprogramming. The severity of the phenotype and the human-relevance of the dose employed, affirm this is an adverse outcome meriting further exploration.
Subject: Endocrinologia
Tecido adiposo
Sexo - Diferenças
language: por
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
Rights: Acesso Aberto
metadata.dc.identifier.doi: https://doi.org/10.3390/ijms21072553
URI: http://hdl.handle.net/1843/56277
Issue Date: 2020
metadata.dc.url.externa: https://www.mdpi.com/1422-0067/21/7/2553
metadata.dc.relation.ispartof: International Journal of Molecular Sciences
Appears in Collections:Artigo de Periódico



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