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http://hdl.handle.net/1843/56514| Type: | Artigo de Periódico |
| Title: | The effect of insulin-induced hypoglycemia on inflammatory markers: a systematic review |
| Authors: | Juliana B.drummond Izabela Guimarães Barbosa Robert Dantzer Antonio l. Teixeira |
| Abstract: | Introduction: The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous.Objective: We aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on inflammatory markers in patients with diabetes as well as non-diabetic subjects.Methods: A systematic search of the literature using the electronic databases MEDLINE and SCOPUS was con ducted through September 2017. Search terms included: “hypoglycemia”,“ insulin”, “cytokines”, and “inflammation”. We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans.Results: Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers.Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypogly cemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers. Conclusion: Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects. |
| Subject: | Hipoglicemia Insulisina |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE SAÚDE MENTAL |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.bbi.2018.05.003 |
| URI: | http://hdl.handle.net/1843/56514 |
| Issue Date: | 4-May-2018 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0889159118301740?via%3Dihub |
| metadata.dc.relation.ispartof: | Brain, Behavior, and Immunity |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| The effect of insulin-induced hypoglycemia on inflammatory markers pdfa.pdf | 412.15 kB | Adobe PDF | View/Open |
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