Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/56522
Type: | Artigo de Periódico |
Title: | Further evidence of accelerated aging in bipolar disorder: focus on gdf-15 |
Authors: | Fangyang Izabela Guimarães Barbosa Erica l. Vieira Moises e. Bauer Natalia p. Rocha Antonio l. Teixeira |
Abstract: | BACKGROUND: Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. METHODS: Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay. RESULTS: The levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001). CONCLUSION: Our findings corroborate the view that BD is an illness associated with accelerated aging. |
Subject: | Transtorno Bipolar Fator 15 de Diferenciação de Crescimento Envelhecimento |
language: | eng |
metadata.dc.publisher.country: | Brasil |
Publisher: | Universidade Federal de Minas Gerais |
Publisher Initials: | UFMG |
metadata.dc.publisher.department: | MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE SAÚDE MENTAL |
Rights: | Acesso Aberto |
metadata.dc.identifier.doi: | https://doi.org/10.1515/tnsci-2018-0004 |
URI: | http://hdl.handle.net/1843/56522 |
Issue Date: | 9-Mar-2018 |
metadata.dc.url.externa: | https://www.degruyter.com/document/doi/10.1515/tnsci-2018-0004/html |
metadata.dc.relation.ispartof: | Translational Neuroscience |
Appears in Collections: | Artigo de Periódico |
Files in This Item:
File | Description | Size | Format | |
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Further evidence of accelerated aging in bipolar disorder focus on gdf-15 pdfa.pdf | 155.07 kB | Adobe PDF | View/Open |
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