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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56546
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dc.creatorLara Lopespt_BR
dc.creatorXiangjiang Guopt_BR
dc.creatorBogdan Yatsulapt_BR
dc.creatorJianming Guopt_BR
dc.creatorYongquan gupt_BR
dc.creatorTúlio Pinho Navarropt_BR
dc.creatorAlan Dardikpt_BR
dc.creatorOcean Setiapt_BR
dc.creatorAfsha Aurshinapt_BR
dc.creatorShirley Liupt_BR
dc.creatorHaidi hupt_BR
dc.creatorToshihiko Isajipt_BR
dc.creatorHaiyang Liupt_BR
dc.creatorTun Wangpt_BR
dc.creatorShun Onopt_BR
dc.date.accessioned2023-07-17T21:48:34Z-
dc.date.available2023-07-17T21:48:34Z-
dc.date.issued2018-
dc.citation.volume9pt_BR
dc.citation.issue1pt_BR
dc.citation.spage188pt_BR
dc.citation.epage16pt_BR
dc.identifier.doihttps://doi.org/10.1186/s13287-018-0938-6pt_BR
dc.identifier.issn1757-6512pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56546-
dc.description.resumoBackground: Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders that result in poor wound healing and poor treatment options. Recently, stem cell therapy has emerged as a new interventional strategy to treat DFU and appears to be safe and effective in both preclinical and clinical trials. However, variability in the stem cell type and origin, route and protocol for administration, and concomitant use of angioplasty confound easy interpretation and generalization of the results. Methods: The PubMed, Google Scholar, and EMBASE databases were searched and 89 preclinical and clinical studies were selected for analysis. Results: There was divergence between preclinical and clinical studies regarding stem cell type, origin, and delivery techniques. There was heterogeneous preclinical and clinical study design and few randomized clinical trials. Granulocyte-colony stimulating factor was employed in some studies but with differing protocols. Concomitant performance of angioplasty with stem cell therapy showed increased efficiency compared to either therapy alone. Conclusions: Stem cell therapy is an effective treatment for diabetic foot ulcers and is currently used as an alternative to amputation for some patients without other options for revascularization. Concordance between preclinical and clinical studies may help design future randomized clinical trials.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofStem Cell Research Therapypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectStem cell therapypt_BR
dc.subjectCell therapypt_BR
dc.subjectDiabetic foot ulcerpt_BR
dc.subjectDiabetic woundpt_BR
dc.subjectCritical limb ischemiapt_BR
dc.subjectWound healingpt_BR
dc.subjectAmputationpt_BR
dc.subject.otherAmputaçãopt_BR
dc.subject.otherCicatrizaçãopt_BR
dc.subject.otherIsquemia Crônica Crítica de Membropt_BR
dc.subject.otherDiabetes Mellituspt_BR
dc.titleStem cell therapy for diabetic foot ulcers: a review of preclinical and clinical researchpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://stemcellres.biomedcentral.com/articles/10.1186/s13287-018-0938-6pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8134-5825pt_BR
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