Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/56546| Type: | Artigo de Periódico |
| Title: | Stem cell therapy for diabetic foot ulcers: a review of preclinical and clinical research |
| Authors: | Lara Lopes Xiangjiang Guo Bogdan Yatsula Jianming Guo Yongquan gu Túlio Pinho Navarro Alan Dardik Ocean Setia Afsha Aurshina Shirley Liu Haidi hu Toshihiko Isaji Haiyang Liu Tun Wang Shun Ono |
| Abstract: | Background: Diabetic foot ulcer (DFU) is a severe complication of diabetes, preceding most diabetes-related amputations. DFUs require over US$9 billion for yearly treatment and are now a global public health issue. DFU occurs in the setting of ischemia, infection, neuropathy, and metabolic disorders that result in poor wound healing and poor treatment options. Recently, stem cell therapy has emerged as a new interventional strategy to treat DFU and appears to be safe and effective in both preclinical and clinical trials. However, variability in the stem cell type and origin, route and protocol for administration, and concomitant use of angioplasty confound easy interpretation and generalization of the results. Methods: The PubMed, Google Scholar, and EMBASE databases were searched and 89 preclinical and clinical studies were selected for analysis. Results: There was divergence between preclinical and clinical studies regarding stem cell type, origin, and delivery techniques. There was heterogeneous preclinical and clinical study design and few randomized clinical trials. Granulocyte-colony stimulating factor was employed in some studies but with differing protocols. Concomitant performance of angioplasty with stem cell therapy showed increased efficiency compared to either therapy alone. Conclusions: Stem cell therapy is an effective treatment for diabetic foot ulcers and is currently used as an alternative to amputation for some patients without other options for revascularization. Concordance between preclinical and clinical studies may help design future randomized clinical trials. |
| Subject: | Amputação Cicatrização Isquemia Crônica Crítica de Membro Diabetes Mellitus |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE CIRURGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1186/s13287-018-0938-6 |
| URI: | http://hdl.handle.net/1843/56546 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://stemcellres.biomedcentral.com/articles/10.1186/s13287-018-0938-6 |
| metadata.dc.relation.ispartof: | Stem Cell Research Therapy |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Stem cell therapy for diabetic foot ulcers_ a review of preclinical and clinical research.pdf | 834.29 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.