Use este identificador para citar o ir al link de este elemento:
http://hdl.handle.net/1843/56610
Tipo: | Artigo de Periódico |
Título: | Impact of multisection and immunohistochemistry in lymph node staging of Gastric Carcinoma – Case series |
Autor(es): | Fernando A. V. Santos Ana P. Drummond-lage Alberto J. A. Wainstein Marco A. Dias-filho Paulo R. Savassi-rocha Túlio Pinho Navarro |
Resumen: | Gastric carcinoma (GC) locoregional recurrence may occur even in cases where the tumor has been completely resected, possibly due to lymph node (LN) micrometastases. It is estimated that in 10% to 30% of cases, LN micrometastases are not detected by a conventional method for histological assessment of LN metastases with hematoxylin-eosin (HE). A cross-sectional study assessed 51 patients with GC by histological evaluation of the LN micrometastases through LN multi sectioning associated with immunohistochemistry analysis with monoclonal antibodies AE1 and AE3. Total gastrectomy was performed in 51% of patients. The total number of resected LN nodes was 1698, with a mean number of resected LN of 33.3 ± 13.2 per surgical specimen, of which 187 had metastasis. After the application of LN multisection and immunohistochemistry, LN micrometastases were found in 45.1% of the cases. LN staging changed in 29.4%, and tumor staging changed in 23.5% of the cases. In patients initially staged as pN0, LN staging and tumor staging changed, both in 19.2% of the cases. In patients initially staged as pN1 or more, LN staging changed in 40.0% of them, and tumor staging changed in 28.0% of the cases. The accuracy of HE for the histological staging of LN tumoral involvement was 76%, which was considered insufficient for CG patients staging. Investigation of LN micrometastasis through LN multisection and immunohistochemistry should be performed, particularly in cases where the presence of blood and lymphatic vessel invasion has been identified after conventional histological analysis, as well as in patients with advanced GC. |
Asunto: | Imuno-Histoquímica Carcinoma |
Idioma: | eng |
País: | Brasil |
Editor: | Universidade Federal de Minas Gerais |
Sigla da Institución: | UFMG |
Departamento: | MED - DEPARTAMENTO DE CIRURGIA |
Tipo de acceso: | Acesso Aberto |
Identificador DOI: | https://doi.org/10.1038/s41598-020-59000-8 |
URI: | http://hdl.handle.net/1843/56610 |
Fecha del documento: | 24-feb-2020 |
metadata.dc.url.externa: | https://www.nature.com/articles/s41598-020-59000-8#rightslink |
metadata.dc.relation.ispartof: | Scientific Reports |
Aparece en las colecciones: | Artigo de Periódico |
archivos asociados a este elemento:
archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Impact of multisection and immunohistochemistry in lymph node staging of Gastric Carcinoma – Case series.pdf | 6.9 MB | Adobe PDF | Visualizar/Abrir |
Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.