Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/56610
Tipo: Artigo de Periódico
Título: Impact of multisection and immunohistochemistry in lymph node staging of Gastric Carcinoma – Case series
Autor(es): Fernando A. V. Santos
Ana P. Drummond-lage
Alberto J. A. Wainstein
Marco A. Dias-filho
Paulo R. Savassi-rocha
Túlio Pinho Navarro
Resumo: Gastric carcinoma (GC) locoregional recurrence may occur even in cases where the tumor has been completely resected, possibly due to lymph node (LN) micrometastases. It is estimated that in 10% to 30% of cases, LN micrometastases are not detected by a conventional method for histological assessment of LN metastases with hematoxylin-eosin (HE). A cross-sectional study assessed 51 patients with GC by histological evaluation of the LN micrometastases through LN multi sectioning associated with immunohistochemistry analysis with monoclonal antibodies AE1 and AE3. Total gastrectomy was performed in 51% of patients. The total number of resected LN nodes was 1698, with a mean number of resected LN of 33.3 ± 13.2 per surgical specimen, of which 187 had metastasis. After the application of LN multisection and immunohistochemistry, LN micrometastases were found in 45.1% of the cases. LN staging changed in 29.4%, and tumor staging changed in 23.5% of the cases. In patients initially staged as pN0, LN staging and tumor staging changed, both in 19.2% of the cases. In patients initially staged as pN1 or more, LN staging changed in 40.0% of them, and tumor staging changed in 28.0% of the cases. The accuracy of HE for the histological staging of LN tumoral involvement was 76%, which was considered insufficient for CG patients staging. Investigation of LN micrometastasis through LN multisection and immunohistochemistry should be performed, particularly in cases where the presence of blood and lymphatic vessel invasion has been identified after conventional histological analysis, as well as in patients with advanced GC.
Assunto: Imuno-Histoquímica
Carcinoma
Idioma: eng
País: Brasil
Editor: Universidade Federal de Minas Gerais
Sigla da Instituição: UFMG
Departamento: MED - DEPARTAMENTO DE CIRURGIA
Tipo de Acesso: Acesso Aberto
Identificador DOI: https://doi.org/10.1038/s41598-020-59000-8
URI: http://hdl.handle.net/1843/56610
Data do documento: 24-Fev-2020
metadata.dc.url.externa: https://www.nature.com/articles/s41598-020-59000-8#rightslink
metadata.dc.relation.ispartof: Scientific Reports
Aparece nas coleções:Artigo de Periódico

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