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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56610
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dc.creatorFernando A. V. Santospt_BR
dc.creatorAna P. Drummond-lagept_BR
dc.creatorAlberto J. A. Wainsteinpt_BR
dc.creatorMarco A. Dias-filhopt_BR
dc.creatorPaulo R. Savassi-rochapt_BR
dc.creatorTúlio Pinho Navarropt_BR
dc.date.accessioned2023-07-18T19:50:05Z-
dc.date.available2023-07-18T19:50:05Z-
dc.date.issued2020-02-24-
dc.citation.volume10pt_BR
dc.citation.issue1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage8pt_BR
dc.identifier.doihttps://doi.org/10.1038/s41598-020-59000-8pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56610-
dc.description.resumoGastric carcinoma (GC) locoregional recurrence may occur even in cases where the tumor has been completely resected, possibly due to lymph node (LN) micrometastases. It is estimated that in 10% to 30% of cases, LN micrometastases are not detected by a conventional method for histological assessment of LN metastases with hematoxylin-eosin (HE). A cross-sectional study assessed 51 patients with GC by histological evaluation of the LN micrometastases through LN multi sectioning associated with immunohistochemistry analysis with monoclonal antibodies AE1 and AE3. Total gastrectomy was performed in 51% of patients. The total number of resected LN nodes was 1698, with a mean number of resected LN of 33.3 ± 13.2 per surgical specimen, of which 187 had metastasis. After the application of LN multisection and immunohistochemistry, LN micrometastases were found in 45.1% of the cases. LN staging changed in 29.4%, and tumor staging changed in 23.5% of the cases. In patients initially staged as pN0, LN staging and tumor staging changed, both in 19.2% of the cases. In patients initially staged as pN1 or more, LN staging changed in 40.0% of them, and tumor staging changed in 28.0% of the cases. The accuracy of HE for the histological staging of LN tumoral involvement was 76%, which was considered insufficient for CG patients staging. Investigation of LN micrometastasis through LN multisection and immunohistochemistry should be performed, particularly in cases where the presence of blood and lymphatic vessel invasion has been identified after conventional histological analysis, as well as in patients with advanced GC.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofScientific Reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectImuno-Histoquímicapt_BR
dc.subjectCarcinomapt_BR
dc.subject.otherImuno-Histoquímicapt_BR
dc.subject.otherCarcinomapt_BR
dc.titleImpact of multisection and immunohistochemistry in lymph node staging of Gastric Carcinoma – Case seriespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.nature.com/articles/s41598-020-59000-8#rightslinkpt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-0289-8953pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-8227-7972pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8134-5825pt_BR
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