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Type:	Artigo de Periódico
Title:	Psychotria viridis: chemical constituents from leaves and biological properties
Authors:	Débora B. S. Soares Lucienir P. Duarte André D. Cavalcanti Fernando C. Silva Ariadne D. Braga Miriam T. P. Lopes Jacqueline Aparecida Takahashi Sidney A. Vieira-filho
Abstract:	The phytochemical study of hexane, chloroform and methanol extracts from leaves of Psychotria viridis resulted in the identification of: the pentacyclic triterpenes, ursolic and oleanolic acid; the steroids, 24-methylene-cycloartanol, stigmasterol and β-sitosterol; the glycosylated steroids 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol; a polyunsaturated triterpene, squalene; the esters of glycerol, 1-palmitoylglycerol and triacylglycerol; a mixture of long chain hydrocarbons; the aldehyde nonacosanal; the long chain fat acids hentriacontanoic, hexadecanoic and heptadenoic acid; the ester methyl heptadecanoate; the 4-methyl-epi-quinate and two indole alkaloids, N,N-dimethyltryptamine (DMT) and N-methyltryptamine. The chemical structures were determined by means of spectroscopic (IR, 1H and 13C NMR, HSQC, HMBC and NOESY) and spectrometric (CG-MS and LCMS-ESI-ITTOF) methods. The study of biologic properties of P. viridis consisted in the evaluation of the acetylcholinesterase inhibition and cytotoxic activities. The hexane, chloroform, ethyl acetate and methanol extracts, the substances 24-methylene-cycloartanol, DMT and a mixture of 3-O-β-D-glucosyl-β-sitosterol and 3-O-β-D-glucosyl-stigmasterol showed cholinesterase inhibiting activity. This activity induced by chloroform and ethyl acetate extracts was higher than 90%. The methanol and ethyl acetate extracts inhibit the growth and/or induce the death of the tumor cells strains B16F10 and 4T1, without damaging the integrity of the normal cells BHK and CHO. DMT also demonstrated a marked activity against tumor cell strains B16F10 and 4T1.
Subject:	Tumores Fitoquímicos
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAE - DEPARTAMENTO DE MÉTODOS E TÉCNICAS DE ENSINO FAE - FACULDADE DE EDUCAÇÃO ICB - DEPARTAMENTO DE FARMACOLOGIA ICX - DEPARTAMENTO DE QUÍMICA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1590/0001-3765201720160411
URI:	http://hdl.handle.net/1843/59346
Issue Date:	2017
metadata.dc.url.externa:	https://www.scielo.br/j/aabc/a/yj9LRqGsz4RZRTh9rVNpy9j/?lang=en
metadata.dc.relation.ispartof:	Academia Brasileira de Ciências
Appears in Collections:	Artigo de Periódico

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