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http://hdl.handle.net/1843/59347| Type: | Artigo de Periódico |
| Title: | A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus |
| Authors: | Gabriel F. Dossantos Jacqueline Aparecida Takahashi |
| Abstract: | The in vitro metabolism of a widespread natural product, trachyloban-19-oic acid (1), by the fungal species Mucor plumbeus was studied in a sucrose-yeast liquid medium. Two products were isolated, and their structures were determined by spectroscopic means as 7β-hydroxytrachyloban-19-oic acid (5) and trachyloban-19-O-β-D-glucopyranosyl ester (6). To the best of our knowledge, compound 6 is herein reported by the first time in the literature. These compounds were assayed for acetylcholinesterase inhibition along with some related compounds. Compound 6 showed the highest acetylcholinesterase inhibitory activity at 10000 µg/mL among the tested compounds, a result (92.89%) comparable to the activity of the positive control, galanthamine (94.21%). Therefore, biotransformation of the natural product 1 by M. plumbeus produced a novel compound with potential as a new lead to develop anti-Alzheimer medicines. |
| Subject: | Biotransformação (Metabolismo) Inibidores Química |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1590/0001-3765201720170240 |
| URI: | http://hdl.handle.net/1843/59347 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://www.scielo.br/j/aabc/a/sWrhpW3MQ8pYtkPDHpq58sK/?lang=en |
| metadata.dc.relation.ispartof: | Academia Brasileira de Ciências |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| A New Acetylcholinesterase Inhibitor from Green Glycosylation of Trachyloban-19-oic Acid by Mucor plumbeus.pdf | 474.08 kB | Adobe PDF | View/Open |
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