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http://hdl.handle.net/1843/61661| Type: | Artigo de Periódico |
| Title: | Oral and oropharyngeal diffuse large B-Cell lymphoma and high-grade B-Cell lymphoma: a clinicopathologic and prognostic study of 69 cases |
| Authors: | Carla Isabelly Rodrigues-Fernandes Débora Lima Pereira Luis Fernando Rivero Kelly Tambasco Bezerra Bruno Augusto Benevenuto de Andrade Mário José Romañach Michele Agostini Javier Rendón Henao Amanda de Farias Gabriel Décio dos Santos Pinto Júnior Manoela Domingues Martins Arnaldo Gonçalves Junior Mateus José de Carvalho Pereira Ricardo Alves Mesquita Ricardo Santiago Gomez Giovanna Ribeiro Souto Alan Roger Santos-Silva Pablo Agustin Vargas Márcio Ajudarte Lopes Oslei Paes de Almeida Flávia Sirotheau Corrêa Pontes Hélder Antônio Rebelo Pontes Ciro Dantas Soares Rommel Mario Rodríguez Burbano Felipe Paiva Fonseca Thayná Melo de Lima Morais Gleyson Kleber do Amaral-Silva Maria Goretti Freire de Carvalho Lucas Lacerda de Souza Fábio Ramôa Pires Teresa Cristina Ribeiro Bartholomeu dos Santos |
| Abstract: | Objective: The objective of this study was to describe the clinicopathological, molecular, and prognostic features of oral/oropharyngeal diffuse large B-cell lymphoma (DLBCL) and high-grade B-cell lymphoma. Study design: All cases were retrieved from 7 Brazilian institutions. Immunohistochemical reactions were performed to confirm the diagnoses and to categorize the tumors. In situ hybridization was used to detect Epstein-Barr virus (EBV) and fluorescence in situ hybridization was used to identify gene rearrangements. Results: Most cases involved the oral cavity (76.8%). Males and females, with a mean age of 60 years, were evenly affected. Tumors mostly presented as painful swellings. Forty cases represented germinal center B-cell type (58%). Five cases presented double-hit translocation and 3 harbored rearrangement for MYC/BCL2/BCL6. EBV was detected in 3 cases (4.3%). The 5-year overall survival was 44.4%. Female sex, presence of pain and ulcer, microscopic "starry sky pattern" and necrosis, co-expression of c-Myc/Bcl2, and translocation of MYC were associated with a lower survival in univariate analysis (P = .05, P = .01, P = .01, P = .03, P = .05, P = .006, P = .05, respectively). Conclusion: Patients affected by oral/oropharyngeal DLBCL have a low survival rate. High-grade B-cell lymphoma (17.7%) and EBV-positive DLBCL, not otherwise specified (4.3%) account for a small number of cases. |
| Subject: | Lymphoma, large B-Cell, diffuse Immunohistochemistry Neoplasms Survival rate Epstein-Barr virus infections Necrosis Prognosis |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.oooo.2020.11.005 |
| URI: | http://hdl.handle.net/1843/61661 |
| Issue Date: | Apr-2021 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S2212440320313328?via%3Dihub |
| metadata.dc.relation.ispartof: | Oral Surgery Oral Medicine Oral Pathology Oral Radiology |
| Appears in Collections: | Artigo de Periódico |
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