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http://hdl.handle.net/1843/63873| Type: | Artigo de Periódico |
| Title: | Direct sequential C-H iodination/organoyl-thiolation for the benzenoid A-ring modification of quinonoid deactivated systems: a new protocol for potent trypanocidal quinones |
| Authors: | Guilherme Augusto de Melo Jardim Willian Xerxes Coelho Oliveira Rossimiriam Pereira de Freitas Rubem Figueiredo Sadok Menna Barreto Thaissa Lúcio Silva Marilia Oliveira Fonseca Goulart Eufrânio Nunes da Silva Júnior |
| Abstract: | We report a sequential C–H iodination/organoyl-thiolation of naphthoquinones and their relevant trypanocidal activity. Under a combination of AgSR with a copper source, sulfur-substituted benzenoid quinones were prepared in high yields (generally >90%). This provides an efficient and general method for preparing A-ring modified naphthoquinoidal systems, recognized as a challenge in quinone chemistry. |
| Subject: | Química orgânica Quinona |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1039/C8OB00196K |
| URI: | http://hdl.handle.net/1843/63873 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://pubs.rsc.org/en/content/articlelanding/2018/ob/c8ob00196k |
| metadata.dc.relation.ispartof: | Organic & Biomolecular Chemistry |
| Appears in Collections: | Artigo de Periódico |
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