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http://hdl.handle.net/1843/65107| Type: | Artigo de Periódico |
| Title: | DNA/RNA hybrid mesoscopic model shows strong stability dependence with deoxypyrimidine content and stacking interactions similar to RNA/RNA |
| Authors: | Erik de Oliveira Martins Vivianne Basílio Barbosa Gerald Weber |
| Abstract: | Despite the importance of DNA/RNA hybrids, a mesoscopic approach is still missing. We developed a mesoscopic model for DNA/RNA hybrids and obtained the complete parametrization from published melting temperatures. The new parameters show very clearly the reduced strength of the hydrogen bond of dArU base pairs, resulting in a weakened stabilization of the double helix and a strong stability dependence on deoxypyrimidine content. The stacking parameters show no correlation to B-DNA, however we obtain a moderate correlation to A-RNA. We discuss some example sequences with variable deoxypyrimidine contents and for polipurine tracts (PPT). |
| Subject: | Biofísica Ácido desoxirribonucleico DNA Hidrogênio |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE FÍSICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.cplett.2018.11.015 |
| URI: | http://hdl.handle.net/1843/65107 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0009261418309291?via%3Dihub |
| metadata.dc.relation.ispartof: | Chemical Physics Letters |
| Appears in Collections: | Artigo de Periódico |
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