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http://hdl.handle.net/1843/70472| Type: | Artigo de Periódico |
| Title: | The use of occlusive dressings: influence on excisional wound healing in animal model |
| Authors: | Mariana Raquel Soares Guillen Eline Lima Borges Gilmara Lopes Amorim Puebla Cassini Vieira Antonio Carlos Martins Guedes Lucíola da Silva Barcelos |
| Abstract: | Purpose: To analyze the in昀氀uence of occlusive dressing on the healing of excisional skin wounds in mice. Methods: Pre-clinical, comparative, and translational study. Mice were divided into three experimental groups: wounds occluded with hydrocolloid (HD) dressings, transparent polyurethane 昀椀lm (TF) dressings, and without occlusion (WO), monitored at three, six and 14 days, with eight animals each. Closure rate, in昀椀ltration of neutrophils and macrophages, measurement of tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) and, histologically, angiogenesis were evaluated. Results: Wound closure was accelerated in the occlusive groups. There was a decrease in TNF-α levels in the HD group when compared to the WO and TF groups. Neutrophils accumulation decreased in the HD group. Increased dosages of macrophages were evidenced in the HD group, compared to the WO and TF groups. Levels of VEGF were increased in the TF and HD groups. Conclusion: It is suggested that the occlusion of wounds modulates the in昀氀ammatory response. |
| Subject: | Wounds and Injuries Occlusive Dressings Descritor em espanhol: Inflammation |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ENF - DEPARTAMENTO DE ENFERMAGEM BÁSICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1590/acb371206 |
| URI: | http://hdl.handle.net/1843/70472 |
| Issue Date: | 2022 |
| metadata.dc.url.externa: | https://doi.org/10.1590/acb371206 |
| metadata.dc.relation.ispartof: | Acta Cirúrgica Brasileira |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| The use of occlusive dressings pdfa.pdf | 410.51 kB | Adobe PDF | View/Open |
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