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http://hdl.handle.net/1843/71502| Tipo: | Artigo de Periódico |
| Título: | MMP-1 and MMP-8 expression in giant-cell fibroma and inflammatory fibrous hyperplasia |
| Autor(es): | Henrique Climeck de Oliveira Ana Maria Trindade Grégio Luciana Reis Azevedo Alanis Sérgio Aparecido Ignácio Jean Nunes dos Santos Antonio Adilson Soares de Lima Aline Cristina Batista Rodrigues Johann André Tschoeke Gabriele Claudino da Cruz Lúcia Noronha Rafaela Scariot de Moraes Ricardo Alves Mesquita Maria Cássia Ferreira de Aguiar Patrícia Carlos Caldeira Marina de Oliveira Ribas |
| Resumen: | The aim of this study is to compare the immunoexpression of metalloproteinases 1 and 8 in giant-cell fibroma, inflammatory fibrous hyperplasia and normal mucosa. Twenty-two cases of giant-cell fibroma, inflammatory fibrous hyperplasia and oral mucosa (control) each were subjected to immunohistochemistry using anti-metalloproteinase-1 and anti-metalloproteinase-8 antibodies. Eight images of each case were captured and analysed through the a) application of a count grid to count the number of positive neutrophils, macrophages, lymphocytes, plasma cells, fibroblasts and blood vessels to obtain the percentage of staining and b) semi-automated segmentation quantifying the stained area in square micrometres. Statistical tests included ANOVA Two-way, Kruskal Wallis and Games-Howell, with a significance level of 5%. An increased percentage of metalloproteinase-1-immunopositive blood vessels were observed in giant-cell fibroma (26.6 ± 22.4; p = 0.02) and inflammatory fibrous hyperplasia (34.3 ± 31.5; p = 0.01) compared with the control group (19.6 ± 9.2). No significant differences in inflammatory cells, fibroblasts and total area of metalloproteinase-1 and −8 were noted among the three groups. Metalloproteinase-1 apparently acts within the pathogenesis of giant-cell fibroma and inflammatory fibrous hyperplasia. |
| Asunto: | Collagen Matrix metalloproteinase 1 Matrix metalloproteinase 8 Immunohistochemistry Hyperplasia Fibroma Mouth mucosa |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | FAO - DEPARTAMENTO DE CLÍNICA |
| Tipo de acceso: | Acesso Restrito |
| Identificador DOI: | https://doi.org/10.1016/j.prp.2016.10.002 |
| URI: | http://hdl.handle.net/1843/71502 |
| Fecha del documento: | dic-2016 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0344033816305313 |
| metadata.dc.relation.ispartof: | Pathology - Research and Practice |
| Aparece en las colecciones: | Artigo de Periódico |
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