Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/71502
Tipo: Artigo de Periódico
Título: MMP-1 and MMP-8 expression in giant-cell fibroma and inflammatory fibrous hyperplasia
Autor(es): Henrique Climeck de Oliveira
Ana Maria Trindade Grégio
Luciana Reis Azevedo Alanis
Sérgio Aparecido Ignácio
Jean Nunes dos Santos
Antonio Adilson Soares de Lima
Aline Cristina Batista Rodrigues Johann
André Tschoeke
Gabriele Claudino da Cruz
Lúcia Noronha
Rafaela Scariot de Moraes
Ricardo Alves Mesquita
Maria Cássia Ferreira de Aguiar
Patrícia Carlos Caldeira
Marina de Oliveira Ribas
Resumo: The aim of this study is to compare the immunoexpression of metalloproteinases 1 and 8 in giant-cell fibroma, inflammatory fibrous hyperplasia and normal mucosa. Twenty-two cases of giant-cell fibroma, inflammatory fibrous hyperplasia and oral mucosa (control) each were subjected to immunohistochemistry using anti-metalloproteinase-1 and anti-metalloproteinase-8 antibodies. Eight images of each case were captured and analysed through the a) application of a count grid to count the number of positive neutrophils, macrophages, lymphocytes, plasma cells, fibroblasts and blood vessels to obtain the percentage of staining and b) semi-automated segmentation quantifying the stained area in square micrometres. Statistical tests included ANOVA Two-way, Kruskal Wallis and Games-Howell, with a significance level of 5%. An increased percentage of metalloproteinase-1-immunopositive blood vessels were observed in giant-cell fibroma (26.6 ± 22.4; p = 0.02) and inflammatory fibrous hyperplasia (34.3 ± 31.5; p = 0.01) compared with the control group (19.6 ± 9.2). No significant differences in inflammatory cells, fibroblasts and total area of metalloproteinase-1 and −8 were noted among the three groups. Metalloproteinase-1 apparently acts within the pathogenesis of giant-cell fibroma and inflammatory fibrous hyperplasia.
Assunto: Collagen
Matrix metalloproteinase 1
Matrix metalloproteinase 8
Immunohistochemistry
Hyperplasia
Fibroma
Mouth mucosa
Idioma: eng
País: Brasil
Editor: Universidade Federal de Minas Gerais
Sigla da Instituição: UFMG
Departamento: FAO - DEPARTAMENTO DE CLÍNICA
Tipo de Acesso: Acesso Restrito
Identificador DOI: https://doi.org/10.1016/j.prp.2016.10.002
URI: http://hdl.handle.net/1843/71502
Data do documento: Dez-2016
metadata.dc.url.externa: https://www.sciencedirect.com/science/article/pii/S0344033816305313
metadata.dc.relation.ispartof: Pathology - Research and Practice
Aparece nas coleções:Artigo de Periódico

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