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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/71502
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dc.creatorHenrique Climeck de Oliveirapt_BR
dc.creatorAna Maria Trindade Grégiopt_BR
dc.creatorLuciana Reis Azevedo Alanispt_BR
dc.creatorSérgio Aparecido Ignáciopt_BR
dc.creatorJean Nunes dos Santospt_BR
dc.creatorAntonio Adilson Soares de Limapt_BR
dc.creatorAline Cristina Batista Rodrigues Johannpt_BR
dc.creatorAndré Tschoekept_BR
dc.creatorGabriele Claudino da Cruzpt_BR
dc.creatorLúcia Noronhapt_BR
dc.creatorRafaela Scariot de Moraespt_BR
dc.creatorRicardo Alves Mesquitapt_BR
dc.creatorMaria Cássia Ferreira de Aguiarpt_BR
dc.creatorPatrícia Carlos Caldeirapt_BR
dc.creatorMarina de Oliveira Ribaspt_BR
dc.date.accessioned2024-07-25T19:01:09Z-
dc.date.available2024-07-25T19:01:09Z-
dc.date.issued2016-12-
dc.citation.volume212pt_BR
dc.citation.issue12pt_BR
dc.citation.spage1108pt_BR
dc.citation.epage1112pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.prp.2016.10.002pt_BR
dc.identifier.issn1618-0631pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/71502-
dc.description.resumoThe aim of this study is to compare the immunoexpression of metalloproteinases 1 and 8 in giant-cell fibroma, inflammatory fibrous hyperplasia and normal mucosa. Twenty-two cases of giant-cell fibroma, inflammatory fibrous hyperplasia and oral mucosa (control) each were subjected to immunohistochemistry using anti-metalloproteinase-1 and anti-metalloproteinase-8 antibodies. Eight images of each case were captured and analysed through the a) application of a count grid to count the number of positive neutrophils, macrophages, lymphocytes, plasma cells, fibroblasts and blood vessels to obtain the percentage of staining and b) semi-automated segmentation quantifying the stained area in square micrometres. Statistical tests included ANOVA Two-way, Kruskal Wallis and Games-Howell, with a significance level of 5%. An increased percentage of metalloproteinase-1-immunopositive blood vessels were observed in giant-cell fibroma (26.6 ± 22.4; p = 0.02) and inflammatory fibrous hyperplasia (34.3 ± 31.5; p = 0.01) compared with the control group (19.6 ± 9.2). No significant differences in inflammatory cells, fibroblasts and total area of metalloproteinase-1 and −8 were noted among the three groups. Metalloproteinase-1 apparently acts within the pathogenesis of giant-cell fibroma and inflammatory fibrous hyperplasia.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPathology - Research and Practicept_BR
dc.rightsAcesso Restritopt_BR
dc.subjectKeywords Collagen Metalloproteinase-8 Metalloproteinase-1pt_BR
dc.subject.otherCollagenpt_BR
dc.subject.otherMatrix metalloproteinase 1pt_BR
dc.subject.otherMatrix metalloproteinase 8pt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherHyperplasiapt_BR
dc.subject.otherFibromapt_BR
dc.subject.otherMouth mucosapt_BR
dc.titleMMP-1 and MMP-8 expression in giant-cell fibroma and inflammatory fibrous hyperplasiapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0344033816305313pt_BR
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