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http://hdl.handle.net/1843/72115| Type: | Artigo de Periódico |
| Title: | COtab: expedient and safe setup for Pd-catalyzed carbonylation chemistry |
| Authors: | Hugo Paul Collin Wallace Junio Reis Dennis Ulsøe Nielsen Anders Thyboe Lindhardt Marcelo Siqueira Valle Rossimiriam Pereira de Freitas Troels Skrydstrup |
| Abstract: | Bench-stable tablets (COtabs) have been developed for the rapid and safe production of carbon monoxide. The tablets can be made in less than 5 min without the use of a glovebox and only require a stock solution of an amine base to liberate a specific quantity of CO in a two-chamber system. The COtabs were tested in five different carbonylation reactions and provided similar yields compared to literature procedures. Finally, a gram-scale reaction was conducted, as well as 13C-isotope labeling of the anticancer drug, olaparib. |
| Subject: | Catalisadores Compostos de carbono Comportos inorgânicos Óxidos Testes químicos e reagentes Agentes antineoplásicos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1021/acs.orglett.9b01423 |
| URI: | http://hdl.handle.net/1843/72115 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | https://pubs.acs.org/doi/10.1021/acs.orglett.9b01423 |
| metadata.dc.relation.ispartof: | Organic Letters |
| Appears in Collections: | Artigo de Periódico |
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