Use este identificador para citar o ir al link de este elemento:
http://hdl.handle.net/1843/SFSA-B3FQHZ
Tipo: | Tese de Doutorado |
Título: | Overcoming quinone deactivation: rhodium catalysed C-H activation as a new gateway for potent trypanocidal prototypes |
Autor(es): | Guilherme Augusto de Melo Jardim |
primer Tutor: | Eufranio Nunes da Silva Junior |
primer miembro del tribunal : | Helio Gauze Bonacorso |
Segundo miembro del tribunal: | Jose Augusto Ferreira Perez Villar |
Tercer miembro del tribunal: | Jose Dias de Souza Filho |
Cuarto miembro del tribunal: | Adao Aparecido Sabino |
Resumen: | |
Abstract: | The following manuscript encompasses all efforts in the development of a methodology that aims for the direct functionalization of the benzenoid and dicarbonyl ring of 1,4-naphthoquinones, referred to as A-ring and B-ring, respectively, via rhodium catalysed C-H activation-functionalization, and all other reactions that have been discovered during the research process. In a first approach, optimization studies were carried out to define the best reactional conditions for C5 and C2-halogenation, followed by the appliance of the optimized methodology in different naphthoquinoidal substrates. In a second part, the recently discovered C-2 halogenation/phenyl selenylation protocol was explored and the new methodology applied to a wild range of 1,4-benzoquinones. The C5-halogenation process opened way for new modifications in the A-ring, such as palladium cross-coupling and copper-catalysed organoyl-thiolation reactions. Finally, all new compounds were evaluated against Trypanosoma cruzi trypomastigote forms, with the majority of them presenting remarkable bioactivity. |
Asunto: | Quinona Chagas, Doença de Química orgânica Catalisadores de metais de transição |
Idioma: | Português |
Editor: | Universidade Federal de Minas Gerais |
Sigla da Institución: | UFMG |
Tipo de acceso: | Acesso Aberto |
URI: | http://hdl.handle.net/1843/SFSA-B3FQHZ |
Fecha del documento: | 20-jul-2018 |
Aparece en las colecciones: | Teses de Doutorado |
archivos asociados a este elemento:
archivo | Descripción | Tamaño | Formato | |
---|---|---|---|---|
tese_de_doutorado_guilherme_jardim.pdf | 28.09 MB | Adobe PDF | Visualizar/Abrir |
Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.