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http://hdl.handle.net/1843/SFSA-B3FQHZ
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DC Field | Value | Language |
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dc.contributor.advisor1 | Eufranio Nunes da Silva Junior | pt_BR |
dc.contributor.referee1 | Helio Gauze Bonacorso | pt_BR |
dc.contributor.referee2 | Jose Augusto Ferreira Perez Villar | pt_BR |
dc.contributor.referee3 | Jose Dias de Souza Filho | pt_BR |
dc.contributor.referee4 | Adao Aparecido Sabino | pt_BR |
dc.creator | Guilherme Augusto de Melo Jardim | pt_BR |
dc.date.accessioned | 2019-08-13T04:43:36Z | - |
dc.date.available | 2019-08-13T04:43:36Z | - |
dc.date.issued | 2018-07-20 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/1843/SFSA-B3FQHZ | - |
dc.description.abstract | The following manuscript encompasses all efforts in the development of a methodology that aims for the direct functionalization of the benzenoid and dicarbonyl ring of 1,4-naphthoquinones, referred to as A-ring and B-ring, respectively, via rhodium catalysed C-H activation-functionalization, and all other reactions that have been discovered during the research process. In a first approach, optimization studies were carried out to define the best reactional conditions for C5 and C2-halogenation, followed by the appliance of the optimized methodology in different naphthoquinoidal substrates. In a second part, the recently discovered C-2 halogenation/phenyl selenylation protocol was explored and the new methodology applied to a wild range of 1,4-benzoquinones. The C5-halogenation process opened way for new modifications in the A-ring, such as palladium cross-coupling and copper-catalysed organoyl-thiolation reactions. Finally, all new compounds were evaluated against Trypanosoma cruzi trypomastigote forms, with the majority of them presenting remarkable bioactivity. | pt_BR |
dc.description.resumo | pt_BR | |
dc.language | Português | pt_BR |
dc.publisher | Universidade Federal de Minas Gerais | pt_BR |
dc.publisher.initials | UFMG | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.subject | Deactivated Systems | pt_BR |
dc.subject | Chagas Disease | pt_BR |
dc.subject | Quinones | pt_BR |
dc.subject | C-H Activation | pt_BR |
dc.subject | Transition Metal Catalysis | pt_BR |
dc.subject | Trypanosoma cruzi | pt_BR |
dc.subject.other | Quinona | pt_BR |
dc.subject.other | Chagas, Doença de | pt_BR |
dc.subject.other | Química orgânica | pt_BR |
dc.subject.other | Catalisadores de metais de transição | pt_BR |
dc.title | Overcoming quinone deactivation: rhodium catalysed C-H activation as a new gateway for potent trypanocidal prototypes | pt_BR |
dc.type | Tese de Doutorado | pt_BR |
Appears in Collections: | Teses de Doutorado |
Files in This Item:
File | Description | Size | Format | |
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tese_de_doutorado_guilherme_jardim.pdf | 28.09 MB | Adobe PDF | View/Open |
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