Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/57582| Type: | Artigo de Periódico |
| Title: | Blood neuron cell-derived microparticles as potential biomarkers in Alzheimer’s disease |
| Authors: | Carolina Antunes Magalhães Henrique Cerqueira Guimarães Marco Túlio Gualberto Cintra Elvis C. C. Mateo Maria Aparecida Bicalho Maria Das Graças Carvalho Lirlândia P. Sousa Paulo Caramelli Karina Braga Gomes Fernanda M. Campos Cristina M. G. Loures Vanessa Gomes Fraga Ana Carolina R. de Oliveira Amanda c Chaves Natália Pessoa Rocha Leonardo Cruz de Souza Raphael d Maia |
| Abstract: | Alzheimer’s disease (AD) is the most frequent cause of dementia, associated with a significant and progressive loss of both cognitive and functional performance [1].Microparticles (MPs) are microvesicles, ranging from 0.1 to 1 µm, released from the cell membrane during its activation and apoptosis. They are involved in cell-cell communication transferring cyto/nuclear proteins, DNA, mRNA and miRNA [2, 3]. Considering that MPs are involved in neuroinflammation and hemostasis, and that levels of several vascular and inflammatory factors were reported to be increased in patients with AD [4], we hypothesized that plasmatic MPs levels (platelet, leukocyte, endothe lial, neuron cell-derived MPs and MPs that express tissue factor [TF]) may be potential biomarkers to AD diagnosis. |
| Subject: | Doença de Alzheimer Disfunção Cognitiva Biomarcadores |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1515/cclm-2018-0483 |
| URI: | http://hdl.handle.net/1843/57582 |
| Issue Date: | 9-Mar-2018 |
| metadata.dc.url.externa: | https://www.degruyter.com/document/doi/10.1515/cclm-2018-0483/html |
| metadata.dc.relation.ispartof: | Clinical Chemistry and Laboratory Medicine |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.