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http://hdl.handle.net/1843/60195| Type: | Artigo de Periódico |
| Title: | Occurrence of BMAA isomers in bloom-impacted lakes and reservoirs of Brazil, Canada, France, Mexico, and the United Kingdom |
| Other Titles: | Ocorrência de isômeros BMAA em lagos e reservatórios afetados pelo florescimento do Brasil, Canadá, França, México e Reino Unido |
| Authors: | Safa Abbes Sung Vo Duy Gabriel Munoz Quoc Tuc Dinh Dana F. Simon Barry Husk Helen M. Baulch Brigitte Vinçon-Leite Nathalie Fortin Charles W. Greer Megan L. Larsen Jason J. Venkiteswaran Felipe Fernando Martínez Jerónimo Alessandra Giani Chris D. Lowe Nicolas Tromas Sébastien Sauvé |
| Abstract: | The neurotoxic alkaloid β-N-methyl-amino-l-alanine (BMAA) and related isomers, including N-(2-aminoethyl glycine) (AEG), β-amino-N-methyl alanine (BAMA), and 2,4-diaminobutyric acid (DAB), have been reported previously in cyanobacterial samples. However, there are conflicting reports regarding their occurrence in surface waters. In this study, we evaluated the impact of amending lake water samples with trichloroacetic acid (0.1 M TCA) on the detection of BMAA isomers, compared with pre-existing protocols. A sensitive instrumental method was enlisted for the survey, with limits of detection in the range of 5–10 ng L−1. Higher detection rates and significantly greater levels (paired Wilcoxon’s signed-rank tests, p < 0.001) of BMAA isomers were observed in TCA-amended samples (method B) compared to samples without TCA (method A). The overall range of B/A ratios was 0.67–8.25 for AEG (up to +725%) and 0.69–15.5 for DAB (up to +1450%), with absolute concentration increases in TCA-amended samples of up to +15,000 ng L−1 for AEG and +650 ng L−1 for DAB. We also documented the trends in the occurrence of BMAA isomers for a large breadth of field-collected lakes from Brazil, Canada, France, Mexico, and the United Kingdom. Data gathered during this overarching campaign (overall, n = 390 within 45 lake sampling sites) indicated frequent detections of AEG and DAB isomers, with detection rates of 30% and 43% and maximum levels of 19,000 ng L−1 and 1100 ng L−1, respectively. In contrast, BAMA was found in less than 8% of the water samples, and BMAA was not found in any sample. These results support the analyses of free-living cyanobacteria, wherein BMAA was often reported at concentrations of 2–4 orders of magnitude lower than AEG and DAB. Seasonal measurements conducted at two bloom-impacted lakes indicated limited correlations of BMAA isomers with total microcystins or chlorophyll-a, which deserves further investigation. |
| Subject: | Lagos Cianobactérias Toxinas de cianobactérias |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE BOTÂNICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.3390/toxins14040251 |
| URI: | http://hdl.handle.net/1843/60195 |
| Issue Date: | 2022 |
| metadata.dc.url.externa: | https://www.mdpi.com/2072-6651/14/4/251 |
| metadata.dc.relation.ispartof: | Toxins |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Occurrence of BMAA isomers in bloom-impacted lakes and reservoirs of Brazil, Canada, France, Mexico, and the United Kingdom.pdf | 7.31 MB | Adobe PDF | View/Open |
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